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Brain Health Research

The following research, data, and publications provide the latest knowledge about the benefits of blood pressure control and other modifiable risk factors as a possible mechanism for reducing the risk of future impaired brain health and cognitive decline.


Dementia Mortality in the United States, 2000–2017
Ellen A. Kramarow and Betzaida Tejada-Vera. National Vital Statistics Reports; Volume 68, Number 2. National Center for Health Statistics. Published March 14, 2019

Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial
The SPRINT MIND Investigators for the SPRINT Research Group; Corresponding author: Jeff D. Williamson. JAMA; original investigation. 2019;321(6):553–561. Published online January 28, 2019. https://doi.org/10.1001/jama.2018.21442

Prevention of Cognitive Impairment With Intensive Systolic Blood Pressure Control
Kristine Yaffe, MD. JAMA; editorial. 2019;321(6):548–549. Published online January 28, 2019. https://doi.org/10.1001/jama.2019.0008

Tracking the landscape of dementia research and resources
Dr. Charlene Liggins, Senior Scientific Program Analyst, Division of Neuroscience, National Institute on Aging. InsideNIA blog. November 28, 2018.

Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective
Matthew Baumgart, Heather M. Snyder, Maria C. Carrillo, Sam Fazio, Hye Kim, Harry Johns. Alzheimer’s & Dementia 11 (2015) 718-726. https://doi.org/10.1016/j.jalz.2015.05.016

Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association
Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW, Seshadri S; American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Council on Cardiovascular Radiology and Intervention, and Council on Cardiovascular Surgery and Anesthesia. Stroke. 2011;42:2672–2713. https://doi.org/10.1161/STR.0b013e3182299496


Preventing Cognitive Decline and Dementia report cover

Preventing Cognitive Decline and Dementia: A Way Forward
This report assesses the current state of knowledge on interventions to prevent cognitive decline and dementia, and informs future research in this area. It also provides recommendations of appropriate content for inclusion in public health messages from the National Institute on Aging. National Academies of Sciences, Engineering, and Medicine; 2017. https://doi.org/10.17226/24782

Dementia prevention, intervention, and care
The Lancet Commission on dementia aims to review the best available evidence and produce recommendations on how to best manage, or even prevent, the dementia epidemic. Gill Livingston, Andrew Sommerlad, Vasiliki Orgeta, Sergi G Costafreda, Jonathan Huntley, David Ames, Clive Ballard, Sube Banerjee, Alistair Burns, Jiska Cohen-Mansfield, Claudia Cooper, Nick Fox, Laura N Gitlin, Robert Howard, Helen C Kales, Eric B Larson, Karen Ritchie, Kenneth Rockwood, Elizabeth L Sampson, Quincy Samus, Lon S Schneider, Geir Selbæk, Linda Teri, Naaheed Mukadam. The Lancet, Vol. 390, No. 10113. Published July 19, 2017.

The State of Aging in America: Data Briefs
These briefs provide public health professionals with the most recent data available on health and aging related conditions—including the importance of brain health, the management of chronic conditions, and caregiving burdens—to help identify needs and mitigate the future effects of a growing older population. National Association of Chronic Disease Directors.

IADRP: International Alzheimer’s Disease and Related Dementias Research Portfolio with brain illustration

International Alzheimer’s Disease and Related Dementias Research Portfolio
This database catalogs research programs supported by public and private organizations both in the U.S. and abroad, categorized using the Common Alzheimer’s and Related Dementias Research Ontology. The resource is maintained by the NIH National Institute of Aging and NIH Library.

Considerations for the Design of a Systematic Review of Care Interventions for Individuals with Dementia and Their Caregivers: Letter Report
This report provides input into the design of an Agency for Healthcare Research and Quality (AHRQ) systematic review of evidence on effective care-related interventions for people with dementia and their caregivers. It also describes potential changes and considerations for the key questions and study design that would result in the most informative and timely evidence review on this topic. National Academies of Sciences, Engineering, and Medicine. 2018. Washington, DC: The National Academies Press. https://doi.org/10.17226/25326

Cognitive aging report cover

Cognitive Aging: Progress in Understanding and Opportunities for Action
This report assesses the public health dimensions of cognitive aging with an emphasis on definitions and terminology, epidemiology and surveillance, prevention and intervention, education of health professionals, and public awareness and education. It also makes specific recommendations for individuals to reduce the risks of cognitive decline with aging. National Academies of Sciences, Engineering, and Medicine (2015). https://doi.org/10.17226/21693


ACPM and its partners are not responsible for the content or recommendations found in the articles or reports developed by other organizations that have been included in this resource center.

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