Community Preventive Services -
Reducing Specific Diseases, Injuries and Impairments-

ATTENTION

Although the research on which this statement was based is out of date, the position/recommendations contained in this policy were reaffirmed by the ACPM Board of Regents on 1/31/2005 until the evidence can be reevaluated.  For the latest evidence review and recommendations, visit U.S. Preventive Services Task Force

Improving Pregnancy Outcomes/
Infant Mortality and Health


ACPM Recommendations:

Folic Acid Fortification of Grain Products in the U.S. to Prevent Neural Tube Defects

ACPM supports a fortification policy of enriched foods with folic acid to reduce the occurrence of NTDs. At this time, a level of at least 350 micrograms appears to be the most appropriate fortification level to maximize the prevention of NTDs, while protecting the health of the general population. The fortification program should be complete with surveillance measures of effectiveness and adverse outcomes. Increasing evidence regarding positive and negative effects of folate supplementation obtained from surveillance data, as well as increased scientific evidence regarding other health benefits of folate consumption, may affect ACPM’s recommendation in the future.

  • See the entire ACPM recommendation at:

Folic Acid Fortification of Grain Products in the U.S. to Prevent Neural Tube Defects. Jennifer Bentley, MD, MPH, Rebecca Ferrini, MD, MPH, and Linda Hill, MD, MPH., San Diego, California. Am J Prev Med. April 1999.